Synthesis

A facile synthesis of 2-substituted isoflavones for immunoassay: Assembly of the isoflavonoid skeleton by means of a novel cyclisation reaction

A Pelter, RS Ward, JL Whalley

Index: Pelter, Andrew; Ward, Robert S.; Whalley, Jacqueline L. Synthesis, 1998 , # 12 p. 1793 - 1802

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Citation Number: 24

Abstract

Abstract: For the purpose of the development of immunoassays for wide-scale screening, isoflavones suitable for attachment to a hapten were prepared. A new cyclisation reaction allowed the direct conversion of 2-(acyloxy) deoxybenzoins to 2-alkylisoflavones by treatment with chlorotrimethylsilane and triethylamine in dimethylformamide. Key words: immunoassay, genistein, cyclisation, 2-(acyloxy) deoxybenzoins, 2-alkylisoflavones

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