Direct conversion of amidoximes to amidines via transfer hydrogenation

M Anbazhagan, DW Boykin, CE Stephens

Index: Anbazhagan, Mariappan; Boykin, David W.; Stephens, Chad E. Synthesis, 2003 , # 16 p. 2467 - 2469

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Citation Number: 13

Abstract

As part of a program of synthesis of diamidines as antimicrobial agents, [10] and in an effort to eliminate the need for hydrogen gas for the efficient conversion of amidoximes to amidines, we have explored the use of ammonium formate (AF) as a hydrogen transfer reagent. Indeed, AF in the presence of Pd/C has been reported to reduce a number of different functional groups. [11] In this paper, we report that the AF/Pd/C system directly and efficiently reduces ...