Synthesis and Crystal Structures of 4-(3-Nitropyridin-2-ylamino) phenol and 4-(3-Aminopyridin-2-ylamino) phenol

…, J Zhao, N Zhang, Y Wang, YY Jiang, YP Feng

Index: Cao, Sheng-Li; Zhao, Jie; Zhang, Nan; Wang, Yue; Jiang, Yu-Yang; Feng, Yu-Ping Journal of Chemical Crystallography, 2011 , vol. 41, # 10 p. 1456 - 1460

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Abstract

Abstract The title compounds, 4-(3-nitropyridin-2-ylamino) phenol (I) and 4-(3-aminopyridin- 2-ylamino) phenol (II), are two intermediates for the synthesis of a potential antitumor agent ABT-751. The reaction of 4-aminophenol with 2-chloro-3-nitropyridine yielded I which was converted into II by reduction. Instead of the Pd/C catalytic hydrogenation described in many literature, reduction with cheap sodium sulfide in aqueous media was utilized for shorting ...