The Journal of Organic Chemistry

A mild and efficient route to Schiff base derivatives of amino acids

MJ O'Donnell, RL Polt

Index: O'Donnell, Martin J.; Polt, Robin L. Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2663 - 2666

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Citation Number: 367

Abstract

R 2 reaction is accomplished by simply stirring equimolar amounts of the two reagents in methylene chloride overnight at room temperature. Filtration and an aqueous workup followed by recrystallization leads to excellent yields of the Schiff bases (3; see Table I). With use of this general procedure, the benzophenone Schiff bases of a variety of glycine alkyl esters (3a-3e) and that from aminoacetonitrile (3f) are easily prepared. In addition, we ...

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