Tetrahedron letters

A facile synthesis of chiral N-protected β-amino alcohols.

M Rodriguez, M Llinares, S Doulut, A Heitz, J Martinez

Index: Rodriguez; Llinares; Doulut; Heitz; Martinez Tetrahedron Letters, 1991 , vol. 32, # 7 p. 923 - 926

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Citation Number: 168

Abstract

Abstract Chiral N-protected β-amino alcohols are easily obtained by NaBH 4 reduction of mixed anhydrides of N-protected α-amino acids in an organic/aqueous medium. The alcohols obtained from side chain or main chain reduction of N-protected aspartic acid are converted in good yields into lactones.

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