Synthesis and evaluation as MRI probe of the trifluoromethylated p-boronophenylalanine and its alcohol derivative

…, T Asano, M Kirihata, Y Yamaguchi, T Wakamiya

Index: Hattori, Yoshihide; Yamamoto, Hitoshi; Ando, Hideya; Kondoh, Hirofumi; Asano, Tomoyuki; Kirihata, Mitsunori; Yamaguchi, Yoshihiro; Wakamiya, Tateaki Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 5 p. 2198 - 2205

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Citation Number: 4

Abstract

Boron-neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical tools for BNCT and MRI, novel compounds containing both the trifluoromethyl group and 10B atom in a single molecule were designed. In the present study, p- boronophenylalanine and p-boronophenylalaninol with the trifluoromethyl group were ...