Efficient synthesis of pyridines via a sequential solventless aldol condensation and Michael addition

GWV Cave, CL Raston

Index: Cave, Gareth W. V.; Raston, Colin L. Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 24 p. 3258 - 3264

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Citation Number: 150

Abstract

The aldol condensation of an enolisable ketone and a benzaldehyde followed by Michael addition of the enone with a second enolisable ketone under solvent free conditions leads to the quantitative formation of a diketone, which can be readily converted to a pyridine (typically> 80% overall yield) via a double condensation in the presence of ammonium acetate in acetic acid, allowing access to a diverse range of oligopyridyls including ...

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