Tetrahedron letters

Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration

SA Weissman, S Lewis, D Askin, RP Volante…

Index: Weissman, Steven A.; Lewis, Stephanie; Askin, David; Volante; Reider, Paul J. Tetrahedron Letters, 1998 , vol. 39, # 41 p. 7459 - 7462

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Citation Number: 25

Abstract

A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%.