Practical and economical approach to synthesize sitagliptin

K Lin, Z Cai, W Zhou

Index: Lin, Kuaile; Cai, Zhengyan; Zhou, Weicheng Synthetic Communications, 2013 , vol. 43, # 24 p. 3281 - 3286

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Citation Number: 4

Abstract

Economic syntheses of sitagliptin phosphate monohydrate, acknowledged as the first dipeptidyl peptidase 4 (DPP-4) inhibitor, have been achieved in an overall yield of 42.4% in four steps from 1-{3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl}-4-(2,4,5- ...