Shape selective recognition of T· A base pairs by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues

S Foister, MA Marques, RM Doss, PB Dervan

Index: Foister, Shane; Marques, Michael A.; Doss, Raymond M.; Dervan, Peter B. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4333 - 4340

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Citation Number: 60

Abstract

Hairpin polyamides selectively recognize predetermined DNA sequences with affinities comparable to naturally occurring proteins. Internal side-by-side pairs of unsymmetrical aromatic rings within the minor groove of DNA distinguish each of the four Watson–Crick base pairs. In contrast, N-terminal ring pairs exhibit less specificity, with the exception of Im/Py targeting G· C base pairs. In an effort to explore the sequence specificity of new ring ...