Guanidino substituted isoindolones as novel glycoprotein IIb-IIIa receptor antagonists
…, AK Gangopadhyay, PG Jagtap, R Tanpure…
Index: Lal, Bansi; Gangopadhyay, Ashok K.; Jagtap; Tanpure, Rajendra; Rao; Gupte, Ravindra D.; Subbarayan; Asudani, Gope Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 11 p. 1815 - 1832
Full Text: HTML
Citation Number: 0
Abstract
Abstract: Design and synthesis of a novel potent glycoprotein IIb-IIIa (GP IIb-IIIa) receptor antagonist based on isoindolone skeleton has been described. This scaffold has been derived from earlier reported pseudopeptides. Synthesis by a novel route has been achieved. Few molecules show very potent in vitro activity. Further identification of probable additional hydrogen bond donor site has been described.
Related Articles:
[Fu, Liqiang; Liu, Xin; Ling, Chenyu; Cheng, Jianjun; Guo, Xingsheng; He, Huili; Ding, Shi; Yang, Yushe Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 814 - 819]
[Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 2 p. 814 - 819]
[Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 2 p. 814 - 819]