Influence of the nucleobase and anchimeric assistance of the carboxyl acid groups in the hydrolysis of amino acid nucleoside phosphoramidates

M Maiti, S Michielssens, N Dyubankova…

Index: Maiti, Munmun; Michielssens, Servaas; Dyubankova, Natalia; Maiti, Mohitosh; Lescrinier, Eveline; Ceulemans, Arnout; Herdewijn, Piet Chemistry - A European Journal, 2012 , vol. 18, # 3 p. 857 - 868

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Citation Number: 16

Abstract

Abstract Nucleoside phosphoramidates (NPs) are a class of nucleotide analogues that has been developed as potential antiviral/antitumor prodrugs. Recently, we have shown that some amino acid nucleoside phosphoramidates (aaNPs) can act as substrates for viral polymerases like HIV-1 RT. Herein, we report the synthesis and hydrolysis of a series of new aaNPs, containing either natural or modified nucleobases to define the basis for their ...

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