1??(substituted benzyl)??3, 4, 5, 6??tetrahydro??2 (1H)??pyrimidones: A series with stimulant and depressant activities

…, TJ Schwan, FL Wessels, NJ Miles

Index: Ellis; Schwan; Wessels; Miles Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 10 p. 1194 - 1198

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Citation Number: 2

Abstract

Abstract A series of 1-(substituted benzyl)-3, 4, 5, 6-tetrahydro-2 (1H)-pyrimidonea was synthesized primarily by catalytic hydrogenation of the corresponding 1-(substituted benzyl)- 2 (1H)-pyrimidone. The pharmacological evaluation of these compounds in mice revealed a unique profile that included evidence of CNS stimulation and depression within the series and in the same compounds. Some members of this series induced signs of only CNS ...