Synthesis of potential metabolites of dibenz [a, j] acridine: dihydro diols and phenols

CA Rosario, GM Holder, CC Duke

Index: Rosario, Christopher A.; Holder, Gerald M.; Duke, Colin C. Journal of Organic Chemistry, 1987 , vol. 52, # 6 p. 1064 - 1072

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Citation Number: 16

Abstract

Dibenz [aj] acridine (1) is a polycyclic azaaromatic hydrocarbon found in tobacco smoke condensate'and urban atmosphere2 and possesses carcinogenic proper tie^.^ It is expected, by analogy with other polycyclic hydrocarbon~,~ that the biological activation of 1 proceeds through dihydro diols and diol epoxides, and metabolism in vitro with liver microsomes from 3-methylcholanthrene pretreated animals has demonstrated the ...