Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 3. 5-(Arylthio)-, 5-(arylsulfinyl)-, and 5-(arylsulfonyl) thiophene-2-sulfonamides

IT Barnish, PE Cross, RP Dickinson…

Index: Barnish; Cross; Dickinson; Parry; Randall Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 959 - 964

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Citation Number: 16

Abstract

Burnish et al. in brain or erythrocytes, or both, the factors determining the importance of the enzyme at each site being the potency of the drug and its comparative ease of entry into both brain and erythrocytes. 1 In order to identify compounds that might increase cerebral blood flow by raising carbon dioxide levels via carbonic anhydrase inhibition, anticonvulsant activity was measured by means of the mouse electroshock test. The anticonvulsant EDm ...