Synthesis of certain hydroxy analogs of the antimalarial drug primaquine and their in vitro methemoglobin-producing and glutathione-depleting activity in human …
…, A Strother, IM Fraser, AJ Verbiscar
Index: Allahyari; Strother; Fraser; Verbiscar Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 407 - 410
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Citation Number: 39
Abstract
A number of hydroxy analogues of the antimalarial drug primaquine [8-[(4-amino-l- methylbutyl) arnino]-G-meth-oxyquinoline] were synthesized and characterized by 'H NMR and mass spectra. Several of the compounds were found to be active in forming methemoglobin in human erythrocytes, particularly in those from glucose-6-phosphate dehydrogenase (GGPD) deficient subjects. Decreased levels of glutathione (GSH) in ...
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