Synthesis of short oligoribonucleotides bearing a 3'-or 5'-terminal phosphate by use of 4, 4', 4"-tris (4, 5-dichlorophthalimido) trityl as a new 5'-hydroxyl protecting …

M Sekine, T Hata

Index: Sekine, Mitsuo; Hata, Tsujiaki Journal of the American Chemical Society, 1986 , vol. 108, # 15 p. 4581 - 4586

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Citation Number: 30

Abstract

Results and Discussion As mentioned above, protection of the amino groups of adenosine and cytidine with the usual acyl groups should be avoided in our approach that involves hydrazine treatment. Therefore, we have chosen a trityl-type protecting group for the above nucleoside bases. Although both DMTr and MMTr are available for adenosine, the former required inconvenient column chromatography in the presence of pyridine because of its ...