Tetrahedron letters

New synthesis of isoquinoline-3-carboxylates

…, H Kollmann, SH Levinson, P Offen, SB Shetzline…

Index: Hiebl, Johann; Kollmann, Hermann; Levinson, Sidney H.; Offen, Priscilla; Shetzline, Steven B.; Badlani, Ruchi Tetrahedron Letters, 1999 , vol. 40, # 45 p. 7935 - 7938

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Citation Number: 19

Abstract

A new and general synthesis of methyl isoquinoline-3-carboxylates is described starting from aromatic 1, 2-dialdehydes by reaction with protected phosphonoglycine derivatives. Methyl 1-oxo-1, 2-dihydroisoquinoline-3-carboxylates are obtained from 2-formylbenzoate derivatives. This new method allows the preparation of isoquinolines having electron- withdrawing groups on the benzene ring.

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