A rapid and convenient synthesis of derivatives of imidazoles under microwave irradiation

N Zhao, YL Wang, JY Wang

Index: Zhao, Na; Wang, Yu-Lu; Wang, Jin-Ye Journal of the Chinese Chemical Society, 2005 , vol. 52, # 3 p. 535 - 538

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Citation Number: 13

Abstract

Abstract An efficient and a quick microwave-assisted synthesis of benzimidazoles and trisubstituted imidazoles was developed. Three benzimidazoles were obtained as a result of the condensation of 1, 2-phenylenediamine with carboxylic acids and acetoacetic ester without catalyst. A series of trisubstituted imidazoles were synthesized by condensation of benzil, aromatic aldehyde and ammonium acetate in the presence of glacial acetic acid.