Pharmaceutical research

Hydrotropic solubilization of paclitaxel: analysis of chemical structures for hydrotropic property

J Lee, SC Lee, G Acharya, C Chang, K Park

Index: Lee, Jaehwi; Lee, Sang Cheon; Acharya, Ghanashyam; Chang, Ching-Jer; Park, Kinam Pharmaceutical Research, 2003 , vol. 20, # 7 p. 1022 - 1030

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Citation Number: 163

Abstract

Abstract Purpose. To identify hydrotropic agents that can increase aqueous paclitaxel (PTX) solubility and to study the chemical structures necessary for hydrotropic properties so that polymeric hydrotropic agents can be synthesized. Methods. More than 60 candidate hydrotropic agents (or hydro-tropes) were tested for their ability to increase the aqueous PTX solubility. A number of nicotinamide analogues were synthesized based on the ...

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