Reaction of esters of 2-substituted 5-pyrimidinecarboxylic acids with hydrazine hydrate

…, V Yakubkene, P Vainilavicius

Index: Tumkevicius; Yakubkene; Vainilavicius Chemistry of Heterocyclic Compounds, 1999 , vol. 35, # 11 p. 1334 - 1336

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Abstract

Abstract The reaction of methyl esters of 2-substituted 5-pyrimidinecarboxylic acids with hydrazine hydrate at 0–5° C results in the nucleophilic substitution of readily eliminating groups (Cl, CH 3 O, CH 3 S) at the position 2 of the pyrimidine ring, and, on the boiling with