Tetrahedron Letters

NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1, 3-dicarbonyl compounds and mercaptonitrile salts

L Luo, L Meng, Q Sun, Z Ge, R Li

Index: Luo, Laichun; Meng, Lanlan; Sun, Qi; Ge, Zemei; Li, Runtao Tetrahedron Letters, 2014 , vol. 55, # 1 p. 259 - 263

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Citation Number: 16

Abstract

Abstract A NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1, 3-dicarbonyl compounds and mercaptonitrile salts has been developed under mild conditions. This transformation involves sequential bromination/SN 2 alkylation/Thorpe–Ziegler cyclization/regio-selective elimination of a–COR group, affording the desired products in moderate to good yields. The sequence of the leaving reactivity of ...