Highly reactive, general and long-lived catalysts for palladium-catalyzed amination of heteroaryl and aryl chlorides, bromides, and iodides: scope and structure– …

Q Shen, T Ogata, JF Hartwig

Index: Shen, Qilong; Ogata, Tokutaro; Hartwig, John F. Journal of the American Chemical Society, 2008 , vol. 130, # 20 p. 6586 - 6596

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Citation Number: 250

Abstract

We describe a systematic study of the scope and relationship between ligand structure and activity for a highly efficient and selective class of catalysts containing sterically hindered chelating alkylphosphines for the amination of heteroaryl and aryl chlorides, bromides, and iodides. In the presence of this catalyst, aryl and heteroaryl chlorides, bromides, and iodides react with many primary amines in high yields with part-per-million quantities of palladium ...

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