Synthesis and Anti??proliferative in??vitro Activity of Two Natural Dihydrostilbenes and their Analogues

WG Zhang, R Zhao, J Ren, LX Ren, JG Lin…

Index: Zhang, Wei-Ge; Zhao, Rui; Ren, Jian; Ren, Li-Xiang; Lin, Jin-Guang; Liu, Dai-Lin; Wu, Ying-Liang; Yao, Xin-Sheng Archiv der Pharmazie, 2007 , vol. 340, # 5 p. 244 - 250

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Citation Number: 12

Abstract

Abstract A total synthetic route for two natural dihydrostilbenes with significant cytotoxicity toward human cancer cell lines,(3-(2-(7-methoxybenzo [d][1, 3] dioxol-5-yl) ethyl) phenol 1a and 6-(3-hydroxyphenethyl) benzo [d][1, 3] dioxol-4-ol 1b), which were isolated from Bulbophyllum odoratissimum Lindl, was developed via Wittig–Horner reaction. The natural products 1a and 1b were obtained in 28% and 20% overall yield, respectively. ...