Novel approaches towards the LTD4/E4 antagonist, LY290154

A Merschaert, P Boquel, JP Van Hoeck…

Index: Organic Process Research and Development, , vol. 10, # 4 p. 776 - 783

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Citation Number: 14

Abstract

... C for 15 h. 4 Preactivation of zinc by 10% aqueous HCl followed by an organic wash and ... S N 2 chlorination step was carried out using the NCS−PPh 3 procedure developed before for ... key intermediate 18 of this latter approach can be obtained in a one-pot process from indoline ...