Novel 8-deaza-5, 6, 7, 8-tetrahydroaminopterin derivatives as dihydrofolate inhibitor: Design, synthesis and antifolate activity

Z Zhang, J Wu, F Ran, Y Guo, R Tian, S Zhou…

Index: European Journal of Medicinal Chemistry, , vol. 44, # 2 p. 764 - 771

Full Text: HTML

Citation Number: 12

Abstract

... Please enable JavaScript to use all the features on this page. European Journal of Medicinal Chemistry. Volume 44, Issue 2, February 2009, Pages 764–771. ... 1 equiv bromine, DMF, 0 °C to rt, 2 h; (j) allyl bromide (3.5 equiv), NaHCO 3 , THF, rt, 24 h. ...

Related Articles:

Palladium-catalyzed silane/siloxane reductions in the one-pot conversion of nitro compounds into their amines, hydroxylamines, amides, sulfonamides, and …

[Rahaim Jr., Ronald J.; Maleczka Jr., Robert E. Synthesis, 2006 , # 19 p. 3316 - 3340]

A potent multisubstrate analog inhibitor of human thymidylate synthetase

[Srinivasan, Ananthachari; Amarnath, Venkataraman; Broom, Arthur D.; Zou, F. C.; Cheng, Yung-Chi Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1710 - 1717]

More Articles...