A Chiral??Pool??Based Approach to the Core Structure of (+)??Hyperforin

JA Richard, DYK Chen

Index: Richard, Jean-Alexandre; Chen, David Y.-K. European Journal of Organic Chemistry, 2012 , # 3 p. 484 - 487

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Citation Number: 6

Abstract

Abstract Asymmetric entry to the bicyclic core structure of (+)-hyperforin is presented. The developed synthetic strategy features a carefully orchestrated stereochemical relay from the single chiral center residing within (–)-Wieland–Miescher ketone and an intramolecular aldol reaction to cast the [3.3. 1] bicyclic scaffold found in a diverse array of polycyclic polyprenylated acylphloroglucinols.