Synthesis

Reductive N-monoalkylation of primary aromatic amines

G Verardo, AG Giumanini, P Strazzolini, M Poiana

Index: Verardo; Giumanini; Strazzolini; Poiana Synthesis, 1993 , # 1 p. 121 - 125

Full Text: HTML

Citation Number: 59

Abstract

Primary aromatic amines 1 with a variety of ring substituents are easily converted to their N- monoalkyl derivatives 3 by a simple variation of the sodium borohydride/sulfuric acid/carbonyl compound procedure previously described for their N-perrnethylations. The procedure is suitable for the or-monodeuterium labelling of the new N-substituent.

Related Articles:

Zirconium Borohydride-a Versatile Reducing Agent for the Reduction of Electrophilic and Nucleophilic Substrates

[Narasimhan; Balakumar Synthetic Communications, 2000 , vol. 30, # 23 p. 4387 - 4395]

Highly chemoselective nitration of aromatic amines using the Ph 3 P/Br 2/AgNO 3 system

[Tetrahedron Letters, , vol. 47, # 38 p. 6879 - 6881]

Optimizing sensitization processes in dinuclear luminescent lanthanide oligomers: selection of rigid aromatic spacers

[Lemonnier, Jean-Francois; Guenee, Laure; Beuchat, Cesar; Wesolowski, Tomasz A.; Mukherjee, Prasun; Waldeck, David H.; Gogick, Kristy A.; Petoud, Stephane; Piguet, Claude Journal of the American Chemical Society, 2011 , vol. 133, # 40 p. 16219 - 16234]

The mechanism of N-alkylation of weak NH-acids by phase transfer catalysis

[Dehmlow, Eckehard V.; Thieser, Rainer; Zahalka, Hayder Ali; Sasson, Yoel Tetrahedron Letters, 1985 , vol. 26, # 3 p. 297 - 300]

Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3

[Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 7 p. 2414 - 2419]

More Articles...