Tetrahedron letters

Chemical modelling of the thymidylate synthase reaction: evidence for the formation of an exocyclic methylene intermediate from analogues of the covalent ternary …

PFC van der Meij, UK Pandit

Index: Meij, Paul F. C. van der; Pandit, Upendra K. Tetrahedron Letters, 1988 , vol. 29, # 42 p. 5445 - 5448

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Citation Number: 4

Abstract

Abstract The intramolecular thiol addition to C (6) in 1-(3-mercaptopropyl)-5- aminomethyluracil derivatives in protic media leads to the formation of bicyclic; 5, 6- dihydrouracil derivatives, which maybe regarded as models of the covalent ternary complex in the thymidylate synthase reaction. Evidence is presented for the formation of an exocyclic methylene intermediate from these model compounds.

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