Computational predictions of binding affinities to dihydrofolate reductase: synthesis and biological evaluation of methotrexate analogues

M Graffner-Nordberg, J Marelius…

Index: Journal of Medicinal Chemistry, , vol. 43, # 21 p. 3852 - 3861

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Citation Number: 33

Abstract

... Journal of Medicinal Chemistry. ... AstraZeneca R&D Lund, SE-221 87 Lund, Sweden; Department of Pharmaceutical Microbiology, Uppsala Biomedical Center, Uppsala University, Box 581, SE-751 23 Uppsala, Sweden; and Department of Internal Medicine, Lund University ...

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