Chemistry Letters

Synthesis of oligoribonucleotides using 4-methoxybenzyl group as a new protecting group of the 2′-hydroxyl group of adenosine

H Takaku, K Kamaike

Index: Takaku, Hiroshi; Kamaike, Kazuo Chemistry Letters, 1982 , p. 189 - 192

Full Text: HTML

Citation Number: 43

Abstract

4-Methoxybenzyl group was introduced directly to the 2′-hydroxyl group from the reaction of adenosine with 4-methoxybenzyl bromide in the presence of sodium hydride. The 2′-O- (4-methoxybenzyl) adenosine can be successfully used in the synthesis of oligoribonucleotides via phosphotriester approach. The 4-methoxybenzyl group was removed rapidly from the oligoribonucleotides by triphenylmethyl fluoroborate and the ...

Related Articles:

Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form

[Henningfeld, Kristine A.; Arslan, Tuncer; Hecht, Sidney M. Journal of the American Chemical Society, 1996 , vol. 118, # 47 p. 11701 - 11714]

Stereochemistry at Phosphorus of the Reaction Catalyzed by m yo-Inositol Monophosphatase

[Cole, Andrew G.; Gani, David Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 21 p. 2685 - 2694]

Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form

[Henningfeld, Kristine A.; Arslan, Tuncer; Hecht, Sidney M. Journal of the American Chemical Society, 1996 , vol. 118, # 47 p. 11701 - 11714]

Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form

[Henningfeld, Kristine A.; Arslan, Tuncer; Hecht, Sidney M. Journal of the American Chemical Society, 1996 , vol. 118, # 47 p. 11701 - 11714]

Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form

[Henningfeld, Kristine A.; Arslan, Tuncer; Hecht, Sidney M. Journal of the American Chemical Society, 1996 , vol. 118, # 47 p. 11701 - 11714]

More Articles...