Microwave-assisted aqueous Suzuki cross-coupling reactions

…, WA König, W Stenzel, T Schotten

Index: Blettner, Carsten G.; Koenig, Wilfried A.; Stenzel, Wolfgang; Schotten, Theo Journal of Organic Chemistry, 1999 , vol. 64, # 11 p. 3885 - 3890

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Citation Number: 216

Abstract

The poly (ethylene glycol) ester of bromo-, iodo-, and triflate-para-substituted benzoates are smoothly cross-coupled with aryl boronic acids (Suzuki reaction) under “ligandless” palladium acetate catalysis in water. The reaction proceeds without organic cosolvent under conventional thermal conditions (70° C, 2 h) and under microwave irradiation (75 W, 2-4 min). The polymeric support remains stable under both reaction conditions. Whereas ...