Tetrahedron

Total synthesis of palmyrolide A and its 5, 7-epi isomers

G Sudhakar, KJ Reddy, JB Nanubolu

Index: Sudhakar, Gangarajula; Reddy, Karla Janardhan; Nanubolu, Jagadeesh Babu Tetrahedron, 2013 , vol. 69, # 11 p. 2419 - 2429

Full Text: HTML

Citation Number: 18

Abstract

Stereoselective total synthesis of palmyrolide A, a 15-membered neuroactive macrolide, was described by adopting a synthetic strategy developed for the proposed structures, and its 5, 7-epi isomers. The strategy was designed in such a way that the set of stereoisomers, which were needed for establishing the absolute configuration of palmyrolide A, could be obtained from one time operation. The diastereoselective hydrogenation of exo-methylene-γ- ...

Related Articles:

Synthesis of fused bicyclic glutarimides

[Chang, Meng-Yang; Chen, Chung-Yi; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2003 , vol. 59, # 38 p. 7547 - 7553]

… products of lipid-containing foods: synthesis and applications of cis-and trans-2-(tetradec-5′-enyl) cyclobutanones and 11-(2′-oxocyclobutyl) undecanoic acid

[Hamilton, Lynne; Stevenson, M. Hilary; Boyd, Derek R.; Brannigan, Ian N.; Treacy, Alan B.; Hamilton, John T. G.; McRoberts, W. Colin; Elliott, Christopher T. Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 2 p. 139 - 146]

Polarity reversal catalysis in radical reductions of halides by N-heterocyclic carbene boranes

[Pan, Xiangcheng; Lacote, Emmanuel; Lalevee, Jacques; Curran, Dennis P. Journal of the American Chemical Society, 2012 , vol. 134, # 12 p. 5669 - 5674]

Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection

[Yu, Wenquan; Gill, Tina; Wang, Lijuan; Du, Yanming; Ye, Hong; Qu, Xiaowang; Guo, Ju-Tao; Cuconati, Andrea; Zhao, Kang; Block, Timothy M.; Xu, Xiaodong; Chang, Jinhong Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6061 - 6075]

Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection

[Yu, Wenquan; Gill, Tina; Wang, Lijuan; Du, Yanming; Ye, Hong; Qu, Xiaowang; Guo, Ju-Tao; Cuconati, Andrea; Zhao, Kang; Block, Timothy M.; Xu, Xiaodong; Chang, Jinhong Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6061 - 6075]

More Articles...