Studies on antianaphylactic agents. 5. Synthesis of 3-(1H-tetrazol-5-yl) chromones, a new series of antiallergic substances

A Nohara, H Kuriki, T Saijo, H Sugihara…

Index: Nohara,A. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, # 1 p. 141 - 145

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Citation Number: 121

Abstract

3-(I H-Tetrazol-5-y1) chromones converted directly to the quinone. A solution of 170 mg (0.47 mmol) of the aminoaldehyde in 32.5 ml of acetone was treated with a solution of 612 mg (2.3 mmol) of potassium nitrosodisulfonate in 16 ml of 0.167 M potassium dihydrogen phosphate and 32.5 ml of acetone. After 20 h the resulting solution was diluted with water and extracted with dichloromethane. This extract was dried (Na2S04) and concentrated ...