Chemical Communications

Efficient copper-free Sonogashira coupling of aryl chlorides with palladium on charcoal

A Komáromi, Z Novák

Index: Komaromi, Anna; Novak, Zoltan Chemical Communications, 2008 , # 40 p. 4968 - 4970

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Citation Number: 48

Abstract

The palladium-catalyzed Sonogashira reaction is one of the most frequently used synthetic tools for the construction of new C(sp)–C(sp 2 ) bonds in organic synthesis. 1 While both aryl iodides 2 and bromides 3 are excellent coupling partners of terminal acetylenes, the achievement of cross couplings on the more practical and accessible aryl chlorides 4 is still challenging. Generally, the Sonogashira reaction required Cu(I) co-catalyst for the achievement of ...

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