Tetrahedron

Synthesis of 3-arylcoumarins through N-heterocyclic carbene catalyzed condensation and annulation of 2-chloro-2-arylacetaldehydes with salicylaldehydes

Y Jiang, W Chen, W Lu

Index: Jiang, Yuansong; Chen, Wanzhi; Lu, Weimin Tetrahedron, 2013 , vol. 69, # 18 p. 3669 - 3676

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Citation Number: 15

Abstract

The condensation reaction of 2-chloro-2-arylacetaldehyde with salicylaldehyde catalyzed by N-heterocyclic carbene (NHC) leading to 3-arylcoumarin was studied. A number of 3- arylcoumarin derivatives were obtained in good to excellent yields via this umpolung reaction. This reaction is facile and experimentally simple and mild.

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