A facile method for oxidation of primary alcohols to carboxylic acids and its application in glycosaminoglycan syntheses

L Huang, N Teumelsan, X Huang

Index: Huang, Lijun; Teumelsan, Nardos; Huang, Xuefei Chemistry - A European Journal, 2006 , vol. 12, # 20 p. 5246 - 5252

Full Text: HTML

Citation Number: 65

Abstract

Abstract A convenient two-step, one-pot procedure was developed for the conversion of primary alcohols to carboxylic acids. The alcohol was first treated with NaOCl and TEMPO under phase-transfer conditions, followed by NaClO 2 oxidation in one pot. This reaction is applicable to a wide range of alcohols and the mild reaction conditions are compatible with many sensitive functional groups, including electron-rich aromatic rings, acid-labile ...