Synthesis of 3-and 5-formyl-4-phenyl-1 H-pyrazoles: promising head units for the generation of asymmetric imine ligands and mixed metal polynuclear complexes
J Olguín, S Brooker
Index: Olguin, Juan; Brooker, Sally New Journal of Chemistry, 2011 , vol. 35, # 6 p. 1242 - 1253
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Citation Number: 7
Abstract
Two synthetic methodologies are reported for the generation of 4-phenyl-1H-pyrazoles substituted at the 3-and/or 5-positions. Functionalisation of the 4-position of dimethyl-4-iodo- 1-(tetrahydropyran-2-yl)-3, 5-pyrazolecarboxylate (10) to produce dimethyl-4-phenyl-1- (tetrahydropyran-2-yl)-3, 5-pyrazolecarboxylate (14) was achieved by a C–C Suzuki– Miyaura cross coupling reaction in water. However, low yields for this reaction led us to ...
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