Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action

…, T Lampe, M Shimada, PG Nell, J Pernerstorfer…

Index: Pohlmann, Jens; Lampe, Thomas; Shimada, Mitsuyuki; Nell, Peter G.; Pernerstorfer, Josef; Svenstrup, Niels; Brunner, Nina A.; Schiffer, Guido; Freiberg, Christoph Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1189 - 1192

Full Text: HTML

Citation Number: 62

Abstract

The pseudopeptide pyrrolidinedione natural products moiramide B and andrimid represent a new class of antibiotics that target bacterial fatty acid biosynthesis. Structure–activity relationship (SAR) studies revealed a high degree of variability for the fatty acid side chain, allowing optimization of physicochemical parameters, and a restricted SAR for the pyrrolidinedione group, indicating major relevance of this subunit for efficient target ...