Chemistry of emeriamine and its analogs and their inhibitory activity in long-chain fatty acid oxidation

S Shinagawa, T Kanamaru, S Harada…

Index: Shinagawa, Susumu; Kanamaru, Tsuneo; Harada, Setsuo; Asai, Mitsuko; Okazaki, Hisayoshi Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1458 - 1463

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Citation Number: 5

Abstract

Emericedins A, B, and C, new betaines having inhibitory activity of long chain fatty acid oxidation, were isolated from the culture broth of Emericella quadrilineata IF0 5859. Their structures were determined by spectroscopic analyses as (R)-3-(acylamino)-4- (trimethylammonio) butyrate (acyl: A, acetyl; B, propionyl; C, n-butyryl). Structural confvmation and assignment of absolute configuration were made by chemical synthesis ...