Tetrahedron Letters

A totally stereocontrolled route to N-methyl-γ-amino-β-hydroxy acids: Asymmetric synthesis of the amino acid component of hapalosin

M Catasús, A Moyano, MA Pericàs, A Riera

Index: Catasus, Monica; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9309 - 9312

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Citation Number: 33

Abstract

A new approach to the synthesis of N-methyl-γ-amino-β-hydroxy acids, compounds that are essential components of several depsipeptides exhibiting highly interesting therapeutic profiles, is presented. Relevant steps in the synthetic sequence involve the totally stereoselective preparation of a protected aminoalkyl epoxide from a highly enantiopure 2, 3- epoxy alcohol, efficient N-methylation and three-step conversion to the desired N-methyl ...

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