Synthesis and biological evaluation of the 1, 5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1 H- …

TD Penning, JJ Talley, SR Bertenshaw…

Index: Journal of Medicinal Chemistry, , vol. 40, # 9 p. 1347 - 1365

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Citation Number: 1714

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. The spatial orientation of the two aromatic rings of the tricyclic inhibitor class was known to be critical for cyclooxygenase inhibition. We found that the two appropriately substituted ...

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