Papain-catalyzed fragment synthesis of protected cholecystokinin derivatives

…, P Majer, J Slaninová, J Hlaváček

Index: Cerovsky, Vaclav; Pirkova, Jana; Majer, Pavel; Slaninova, Jirina; Hlavacek, Jan Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 7 p. 1873 - 1882

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Abstract

Abstract Sodium salts of methyl esters of N-tert-butyloxycarbonyl-β-tert-butylaspartyl-O 4- sulfotyrosine (II) or N-tert-butyloxycarbonyl-O 4-sulfotyrosine (III) were condensed with amino components derived from peptide amides IVb-IVe and IVg (simulating the carboxy- terminal part of cholecystokinin) under catalysis with papain. Rates and yields of conversion of these peptides to the corresponding derivatives Ib-If were compared with the results ...

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