Synthesis, structure-activity relationships, and pharmacological evaluation of a series of fluorinated 3-benzyl-5-indolecarboxamides: identification of 4-[[5-[((2R)-2- …

RT Jacobs, PR Bernstein, LA Cronk…

Index: Jacobs, Robert T.; Bernstein, Peter R.; Cronk, Laura A.; Vacek, Edward P.; Newcomb, Lisa F.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1282 - 1297

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Citation Number: 22

Abstract

Since their discovery in 1979, the peptidoleukotrienes LTC4 (11, LTD4 (21, and LTE4 (3) have been the subject of intense exploration. This interest lies in the fact that the leukotrienes (LTs) are potent constrictors of smooth muscle and, as such, have been ...