Tetrahedron letters

Total chiral synthesis of azole antifungals via α-hydroxylation of ketones

D Gala, DJ DiBenedetto, I Mergelsberg, M Kugelman

Index: Gala, Dinesh; DiBenedetto, Donald J.; Mergelsberg, Ingrid; Kugelman, Max Tetrahedron Letters, 1996 , vol. 37, # 45 p. 8117 - 8120

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Citation Number: 23

Abstract

The use of camphorsulfonyl oxaziridines for the preparation of 2′, 4′-difluoro-(R)-2- hydroxypropiophenone,(2), a key intermediate for the synthesis of azole antifungals Sch 42427 and ER-30346 (1) in excellent enantiomeric excess and high chemical yield is described.