Hydride reagents for stereoselective reductive amination. An improved preparation of 3-endo-tropanamine

JM McGill, ES Labell, MA Williams

Index: McGill, John M.; Labell, Elizabeth S.; Williams, MaryAnn Tetrahedron Letters, 1996 , vol. 37, # 23 p. 3977 - 3980

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Citation Number: 34

Abstract

The reductive amination of substituted cyclohexanones with sodium triacyloxy-borohydrides derived from NaBH4 and various carboxylic acids provides highly diastereoselective conversions to protected axial amines. This method was applied to the stereoselective preparation of 3-endo-tropanamine.