Iridium-Catalyzed Asymmetric Hydrogenation Yielding Chiral Diarylmethines with Weakly Coordinating or Noncoordinating Substituents

…, M Engman, A Paptchikhine, J Bergquist…

Index: Tolstoy, Paeivi; Engman, Mattias; Paptchikhine, Alexander; Bergquist, Jonas; Church, Tamara L.; Leung, Abby W.-M.; Andersson, Pher G. Journal of the American Chemical Society, 2009 , vol. 131, # 25 p. 8855 - 8860

Full Text: HTML

Citation Number: 50

Abstract

Diarylmethine-containing stereocenters are present in pharmaceuticals and natural products, making the synthetic methods that form these chiral centers are important in industry. We have applied iridium complexes with novel N, P-chelating ligands to the asymmetric hydrogenation of trisubstituted olefins, forming diarylmethine chiral centers in high conversions and excellent enantioselectivities (up to 99% ee) for a broad range of ...