Canadian Journal of Chemistry

Stereospecific synthesis of cis-and trans-2-(3, 4, 5-trimethoxyphenyl)-cyclopropylamines

PD Cooper

Index: Cooper,P.D. Canadian Journal of Chemistry, 1970 , vol. 48, p. 3882 - 3888

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Citation Number: 11

Abstract

The title compounds were synthesized as models for examining stereochemical requirements of the mescaline receptor. By analogy with indolic psychotomimetic drugs, the pseudo-indolic structure of the cis compound should endow it with greater psychotomimetic activity than the trans isomer might possess. A special synthetic sequence was obligatory for the preparation of the cis isomer because the usual intermediates were either unreactive ...

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