Design and synthesis of dipeptide mimetics of the brain-derived neurotrophic factor

TA Gudasheva, AV Tarasyuk, SV Pomogaibo…

Index: Gudasheva; Tarasyuk; Pomogaibo; Logvinov; Povarnina; Antipova; Seredenin Russian Journal of Bioorganic Chemistry, 2012 , vol. 38, # 3 p. 243 - 252 Bioorg. Khim., 2012 , vol. 38, # 3 p. 280 - 290,11

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Citation Number: 8

Abstract

Abstract Low-molecular-weight mimetics of loops 1 and 4 of the brain-derived neurotrophic factor (BDNF) have been designed and synthesized. The compounds represent monomeric and dimeric amides of N-acyldipeptides. Their dipeptide fragments coincide in sequence with the central regions of beta-turns of the corresponding neurotrophin loops, and acyl groups are the bioesosteres of preceding amino acid residues. Hexa-or ...