Potential antitumor agents. 36. Quantitative relationships between experimental antitumor activity, toxicity, and structure for the general class of 9-anilinoacridine …

…, GJ Atwell, C Hansch, A Panthananickal…

Index: Denny, William A.; Cain, Bruce F.; Atwell, Graham J.; Hansch, Corwin; Panthananickal, Augustine; Leo, A. Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 276 - 300

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Citation Number: 172

Abstract

Quantitative relationships (QSAR) have been derived between antileukemic (L1210) activity and agent physicochemical properties for 509 tumor-active members of the general class of 9-anilinoacridines. One member of this class is the clinical agent m-AMSA (NSC 249992). Agent hydrophobicity proved a significant but not a dominant influence on in vivo potency. The electronic properties of substituent groups proved important, but the most significant ...